Current trends in COVID-19 diagnosis and its new variants in physiological fluids: Surface antigens, antibodies, nucleic acids, and RNA sequencingReview article Published on 2022-12-012022-10-05 Journal: TrAC Trends in Analytical Chemistry [Category] 바이오마커, 변종, 진단, 치료기술, [키워드] addressed antibodies antibody Antigen antigens Beta Biomarker biosensors Blood body fluid circulation clustered regularly interspaced short palindromic repeats COVID-19 COVID-19 diagnosis COVID-19 virus diagnosis CRISPR Critical current Delta Detection sensitivity diagnostic early stage ELISA enzyme-linked immunosorbent enzyme-linked immunosorbent assay Gamma Infection isothermal amplification lateral flow immunoassay LFIA limit Loop-mediated isothermal amplification microarray analysis Microarray assays Mutation nucleic acid nucleic acids omicron outbreak overcome palindromic repeat physiological provide Rapid reduce reverse transcriptase-polymerase chain reaction reverse transcription RNA sequencing RT-LAMP RT-PCR Saliva SARS-CoV-2 Semen specificity Spread surface Urine variant variants virus viruses [DOI] 10.1016/j.trac.2022.116750 [Article Type] Review article
Omicron BA.1 and BA.2 variants increase the interactions of SARS-CoV-2 spike glycoprotein with ACE2Article Published on 2022-12-012022-11-16 Journal: Journal of molecular graphics & modelling [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] ACE2 ACE2 receptor Affect angiotensin-converting enzyme 2 Area B.1.1.529 binding binding efficiency binding free energy conformation domain dominant explicit full-length glycans glycoprotein host cells hydrophobic interaction infect Infection initiated Interaction interactions ions Mechanics MMPBSA molecular dynamics Molecular dynamics simulation molecular dynamics simulations mutated Mutation omicron Omicron variant performed RBD RBD-ACE2 receptor residue Salt Bridge SARS-CoV-2 SARS-CoV-2 spike glycoprotein Simulation spike spike glycoprotein spike glycoprotein. strain surface the receptor-binding domain trajectory variant variant of SARS-CoV-2 variants wild-type [DOI] 10.1016/j.jmgm.2022.108286 PMC 바로가기
SARS-CoV-2 air and surface contamination in residential settingsArticle Published on 2022-10-272022-11-15 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] absence Contamination COVID-19 patient determine evaluate fraction highest investigated Isolation methodology mild symptoms occur occurred Occurrence Particles performed persistence positive SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2-infected patient selected surface symptom onset the patient Transmission viability virus virus particle [DOI] 10.1038/s41598-022-22679-y PMC 바로가기
SARS-CoV-2 Contamination of Ambulance Surfaces and Effectiveness of Routine Decontamination Procedure: A Classic Hygiene Lesson for A Novel PathogenArticle Published on 2022-10-212022-11-16 Journal: International Journal of Environmental Research an [Category] COVID19(2023년), SARS, 치료기술, [키워드] Ambulance bypassed classic condition Contamination COVID-19 COVID-19 emergency COVID-19 patient COVID-19 patients decontamination Effectiveness Efficacy emergency medical services (EMS) FIVE glove health authorities healthcare-associated infection (HAI) Infection investigated Italy lesson medical service medical-transport-associated infection (MTAI) molecular MONITOR novel oxygen Patient positive prehospital emergency medicine. RNA extraction routine RT-qPCR SARS-CoV-2 selected surface swabs tested Transport was performed with COVID-19 [DOI] 10.3390/ijerph192013646 PMC 바로가기
Wastewater-based epidemiology in countries with poor wastewater treatment – Epidemiological indicator function of SARS-CoV-2 RNA in surface waters폐수 처리가 열악한 국가의 폐수 기반 역학 - 지표수에서 SARS-CoV-2 RNA의 역학 지표 기능Article Published on 2022-10-152022-09-11 Journal: The Science of the total environment [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법, 치료제, [키워드] adaptation adoption affected alternative analysed applied approach Bacteria Belgrade collected complex complex systems Concentration country COVID-19 Danube effort epidemiological epidemiological purposes Epidemiology Factor Factors Faecal pollution Genes Genetic human populations identify indicated methodology N1 and N2 nucleocapsid outbreak parameter physicochemical primer set primer sets Protein qualitative data quantification quantified Quantitative recipient river RNA RT-qPCR SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 surveillance Sava Serbia surface Surface waters Surveillance Treatment Untreated wastewaters. Volume water [DOI] 10.1016/j.scitotenv.2022.156964 PMC 바로가기 [Article Type] Article
Recent Advances of Representative Optical Biosensors for Rapid and Sensitive Diagnostics of SARS-CoV-2Article Published on 2022-10-122022-11-15 Journal: Biosensors [Category] COVID19(2023년), SARS, 치료기술, [키워드] advance biosensor Corona COVID-19 Diagnosis diagnostic diagnostics disadvantage enhancement equipment explained high accuracy IMPROVE infected patients inherent limit operator optical optical biosensors outbreak pandemic Plasmon point-of-care point-of-care diagnostics. polymerase chain Rapid recent required Research resonance reverse transcription RT-PCR SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 vaccines sensitive sensitivity Sensitivity and specificity SPR surface time-consuming virus [DOI] 10.3390/bios12100862 PMC 바로가기
Reduced Cell Surface Levels of C-C Chemokine Receptor 5 and Immunosuppression in Long Coronavirus Disease 2019 SyndromeArticle Published on 2022-09-302022-11-16 Journal: Clinical Infectious Diseases: An Official Publicat [Category] Fulltext, MERS, 유전자 메커니즘, [키워드] antibody Blood CCR5 Cell clinical COVID exploratory immune Immunosuppression Leronlimab Level Long long COVID. mechanism normalized placebo-treated participants Registration Responder significantly increased surface symptomatic treated Trial [DOI] 10.1093/cid/ciac226 PMC 바로가기
Identification of SARS-CoV-2 Main Protease Inhibitors from a Library of Minor Cannabinoids by Biochemical Inhibition Assay and Surface Plasmon Resonance Characterized Binding AffinityArticle Published on 2022-09-192022-11-15 Journal: Molecules [Category] SARS, 치료제, [키워드] activity acute respiratory syndrome affinity binding binding affinity biochemical biochemical assay cannabinoid chemotype coronavirus coronavirus disease COVID-19 decarboxylation Effect evaluated Evidence finding identification in silico inhibition inhibitor inhibitory effect library M pro main protease (Mpro) minor minor cannabinoids molecular docking molecular interaction Plasmon protease Protein Replication reported resonance SARS-CoV-2 SPR structure and activity relationship Support surface Surface plasmon resonance. the binding affinity therapeutic target [DOI] 10.3390/molecules27186127 PMC 바로가기
Surface Inactivation of Highly Mutated SARS-CoV-2 Variants of Concern: Alpha, Delta, and OmicronArticle Published on 2022-09-122022-11-16 Journal: Biomacromolecules [Category] SARS, 변종, [키워드] adaptive Alpha Antiviral Complete Degradation Delta dominant effective Evolution Face mask glycosylated inactivation independent induce Infection ingestion Mask mice mutations non-toxic omicron Omicron variant pandemic physical barrier Polymer reduction SARS-CoV-2 SARS-CoV-2 transmission Spike protein Spread surface Transmission Vaccine variant variants variants of concern viral genome viral membrane virion virulence virus VoC VOCs waning immunity [DOI] 10.1021/acs.biomac.2c00801 PMC 바로가기
Metalloproteinase-Dependent and TMPRSS2-Independent Cell Surface Entry Pathway of SARS-CoV-2 Requires the Furin Cleavage Site and the S2 Domain of Spike ProteinArticle Published on 2022-08-302022-11-16 Journal: mBio [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] ACE2 ADAM10 addition bind Cell cell death cell interaction cleavage cleaved complex condition contributed coronavirus SARS-CoV COVID-19 develop domain effective element endosomal pathway entry pathway evade furin furin cleavage motif highly pathogenic Host host protease human coronaviruses identify Immunity independent Infection infection mechanism inhibitor involved membrane membrane fusion metalloproteinase organ damage Pathogenesis pathogenesis of COVID-19 pathway Prevent priming provide required S1/S2 boundary S2 domain SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein selective sequence siRNAs Site spike Spread surface surface receptor syncytium formation the spike protein therapeutic agent therapeutic target Therapies TMPRSS2 unique vaccination variants virus entry Virus entry. virus variant [DOI] 10.1128/mbio.00519-22 PMC 바로가기